At that point OSU had a 10-9 advantage. Missouri went on a 7-0 run before the Cowboys scored their next basket. The basket after that came after an 11-0 Tiger spurt. No. 3 Missouri outscored Oklahoma State 32-10 after Nash left the floor.
But it wasn't just that. In the first half Missouri made shots (59.3 percent), OSU didn't (35.7), resulting in a 44-22 halftime deficit that swelled to 35 with just under seven minutes remaining in the game.
When the Cowboys (12-14, 5-8 Big 12) shots weren't dropping, the shot selection got worse and the Tigers pounced on their home floor, where they improved to 15-0 this season and 66-3 with this senior class.
Senior guard Keiton Page got hot late, scoring 14 points in the final 5 minutes and change to pull the score closer at the end but the Tigers were dominant, as they have been the vast majority of the season to the tune of a 24-2 record and a first-place tie in the Big 12 at 11-2.
Page led all scorers with 23, including 5-of-9 from 3. Forward Michael Cobbins had a strong game in the paint with 12 points on 6-of-7 shooting to go with seven rebounds, two blocks and no turnovers.
Nash finished with 11 to round out the double-digit scorers for the Pokes. Brown had nine points, five assists, three rebounds and two steals with two turnovers and Brian Williams scored eight and tallied three assists.
The Cowboys received more help from the bench, as far as minutes played, Wednesday. Cezar Guerrero played 14 minutes and finished with five assists. Philip Jurick played more than most expected, earning 19 minutes in his first real meaningful action since he was injured prior to OSU's loss at Texas A&M on Jan. 28. He finished with two points, four boards and a block.
Missouri had great scoring balance with five in double figures. Marcus Denmon led the Tigers with 17, Ricardo Ratliffe and Michael Dixon had 15 each, and Phil Pressey and Kim English each chipped in 13.
With the win, Missouri's senior class won it's 101st game to become the winningest group in Tiger basketball history.
Oklahoma State's brutal two-game road trip is now over and the Pokes return home to face the Texas Longhorns at 3 p.m. on Saturday in Gallagher-Iba Arena.